Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA

Although many clinicopathological studies of malignant melanoma of the conjunctiva have been reported, there have been no studies of the expression and gene mutations of KIT and PDGFRA in melanoma of the conjunctiva. A 69-year-old Japanese woman consulted our hospital because of black mass (0.7 × 0.7 × 0.6 cm) in the conjunctiva. A biopsy was taken. The biopsy showed malignant epithelioid cells with melanin deposition. Immunohistochemically, the tumor was positive for S100 protein, HMB45, p53, Ki-67 (labeling=30%), KIT and PDGFRA. The tumor was negative for pancytokeratins (AE1/3 and CAM5.2). A genetic analysis using PCR-direct sequencing revealed no mutations of KIT gene (exons 9, 11, 13, and 17) and PDGFRA gene (exons 12 and 18). The pathological diagnosis was conjunctival melanoma. Despite chemotherapy, the patient developed multiple metastases of melanoma, and died of melanoma 7 years after the biopsy. In conclusion, the author reported a case of melanoma of conjunctive expressing KIT and PDGFRA proteins without gene mutations of KIT and PDGFRA

A search for cyclotron resonance features with INTEGRAL

We present an INTEGRAL observation of the Cen-Crux region in order to search the electron cyclotron resonance scattering features from the X-ray binary pulsars. During the AO1 200ks observation, we clearly detected 4 bright X-ray binaries, 1 Seyfert Galaxy, and 4 new sources in the field of view. Especially from GX301-2, the cyclotron resonance feature is detected at about 37 keV, and width of 3--4 keV. In addition, the depth of the resonance feature strongly depends on the X-ray luminosity. This is the first detection of luminosity dependence of the resonance depth. The cyclotron resonance feature is marginally detected from 1E1145.1-6141. Cen X-3 was very dim during the observation and poor statistics disable us to detect the resonance features.These are first INTEGRAL results of searching for the cyclotron resonance feature.Comment: 4pages, 8figures, To be published in the Proceedings of the 5th INTEGRAL Workshop: "The INTEGRAL Universe", February 16-20, 2004, Munic

Accreted Paleoproterozoic eolian beds and dolerite sills in the Miocene Siwalik belt, central Nepal, and their origin

Abstract HKT-ISTP 2013 A

Energy Spectra and Normalized Power Spectral Densities of X-Ray Nova GS 2000+25

The X-ray energy spectra and Normalized Power Spectral Densities (NPSDs) of an X-ray nova, GS 2000+25, were investigated. The X-ray energy spectra of the source consist of two components: a hard component, which can be represented by a power-law, and an ultra-soft component, represented by radiation from an optically-thick accretion disk (the disk component). In a model in which the power-law component is the Compton-scattered radiation, it is found that the temperature of the incident blackbody radiation to the Compton cloud decrease from 0.8 keV to 0.2 keV according to the decay of the intensity, which coincides with that of the inner accretion disk. When the source changed from the high-state to the low-state, both the photon index of the power-law component (or Compton y-parameter) and the NPSD of the hard component dramatically changed as did GS 1124-683. That is, the photon index changed from 2.2--2.6 to 1.7--1.8 and the absolute values of the NPSDs at 0.3 Hz of the hard component in the low-state became about 10-times larger than those of the hard component in the high-state. These X-ray properties were similar to those of other black-hole candidates, such as Cyg X-1, GX 339-4, and LMC X-3.Comment: 24 pages, text only, Full version is published in PASJ 54, 609-627 (2002

Performance Prediction Method Considering Shock Wave in Nozzle for High-Voltage Circuit Breaker

Interrupting-performance indexes that reflect the physical properties of gas flow are proposed for a breaker terminal fault of a high-voltage circuit breaker. A method of evaluating the shock wave and flow velocity was developed that uses a theoretical equation of supersonic flow which takes into account the nozzle’s shape and stagnation pressure. The predicted flow velocities and positions at which the shock wave forms have strong correlations with the test results

Infrared Imaging of the Gravitational Lens PG 1115+080 with the Subaru Telescope

We present high spatial resolution images of the gravitational-lens system PG 1115+080 taken with the near-infrared camera (CISCO) on the Subaru telescope. The FWHM of the combined image is $0.''32$ in the $K'$-band, yielding spatial resolution of $0.''14$ after a deconvolution procedure. This is a first detection of an extended emission adjacent to the A1/A2 components, indicating the presence of a fairly bright emission region with a characteristic angular radius of $\sim$ 5 mas (40 pc). The near-infrared image of the Einstein ring was extracted in both the $J$ and $K'$ bands. The $J-K'$ color is found to be significantly redder than that of a synthetic model galaxy with an age of 3 Gyr, the age of the universe at the quasar redshift.Comment: 11 pages, 6 figures. Accepted for publication in PASJ(2000